polymorphism of Insulin-like growth factor-I [IGF-I] is related to osteoporosis and bone mineral density in postmenopausal population

ABSTRACT

It has been shown that Insulin-like growth factor-1 [IGF-1] may be related with bone mineral density [BMD] or osteoporosis. But there are few evidences on the role of genetic variation of IGF-1 on the BMD or osteoporosis. We observed the relationship between polymorphisms of IGF-1[rs35767, rs2288377 and rs5742612] with osteoporosis and BMD in the postmenopausal female population in our study. A total of 216 postmenopausal women with a primary diagnosis of osteoporosis and 220 normal healthy women were included in the study. Genomic DNA of IGF-1 rs35767, rs2288377 and rs5742612 was extracted from the whole blood using QIAamp blood DNA mini kits [QIAGEN, Hilden, Germany] according to the methods recommended by the manufacturer. We found that T allele of rs35767 had higher increased risk of osteoporosis [OR=1.34, 95%CI=1.0- 1.81]. Those carrying T allele of rs35767 had a significant lower BMD at L1-L4 vertebrae, femoral neck, total hip and trochanter when compared with those carrying C allele [P < 0.05]. In addition, the BMD of L1-L4 vertebrae, femoral neck, total hip and trochanter decreased by 2.09%, 3.74%, 3.52% and 2.54% in women carrying T alleles compared with those carrying C alleles. Our study suggests that polymorphism in IGF-I rs35767 was significantly associated with BMD and osteoporosis in postmenopausal female population, and polymorphism of rs35767 could be a marker for lower BMD and risk of osteoporosis