Lack of correlation between plasma neuropeptide Y and typical and atypical febrile seizures

ABSTRACT

It is known that neuropeptide Y which is widely distributed throughout the central nervous system is able to prevent seizures in animals. There are limited studies about the role of neuropeptide Y in febrile seizures. This study was conducted to evaluate the association between plasma neuropeptide Y level and febrile seizures in children. Seventy six patients with typical and atypical febrile seizures [each group 38 patients] and 38 sex and age matched control subjects were enrolled. The mean plasma levels of neuropeptide Y in typical and atypical febrile seizures were 90.60 +/- 28.01 and 97.34 +/- 41.27 pmol/l respectively. This value in control group was 88.94 +/- 32.66 pmol/l. There was no significant differences between groups regarding plasma neuropeptide Y level [P=0.532]. Also, there was no significant difference in comparison with case groups [P=0.40]. This study revealed that there is no association between plasma neuropeptide Y and febrile seizures