Relationship of adiponectin level with glycemic status and lipid profile in type 2 diabetic men
Biomedica. 2013; 29 (3): 131-135
in English
| IMEMR
| ID: emr-152304
ABSTRACT
To determine serum adiponectin level, glycemic status and lipid profile in type 2 diabetic men belonging to Khyber Pakhtunkwa [KPK], and to find any possible relationship between them. Thirty six healthy adult males and thirty six type 2 diabetic males were randomly selected in a cross - sectional study. After an overnight fasting their blood samples were taken and analyzed for serum adiponectin, glycosylated hemoglobin [HbA[1]c], fasting blood glucose [FBG] and lipid profile including total cholesterol [TC], triglycerides [TG], low - density lipoprotein cholesterol [LDL - C], high - density lipoprotein cholesterol [HDL - C] and very low lipoprotein cholesterol [VLDL - C]. Type 2 diabetic males when compared to healthy males showed significantly low levels of serum adiponectin [3.2 +/- 1.3 vs. 11.06 +/- 2.5, P = 0.01] and HDL - C [32.4 +/- 9.6 vs. 42.4 +/- 8.6, p = 0.01] and significantly high level of FBG [190.4 +/- 83.9 vs. 86.8 +/- 16.7, p = 0.01], HbA[1]c [8.8 +/- 1.8 vs. 5.2 +/- 0.3, p = 0.01] and LDL - C [137.7 +/- 33.4 vs. 115.9 +/- 29.4]. Serum adiponectin level showed a significant negative correlation with FBG [r - 0.596; p = 0.01], HbA[1]c [r - 0.695; p = 0.01], TC [r - 0.758; p = 0.01], TG [r - 0.747; p = 0.01] and LDL - C [r - 0.754; p = 0.01] in type 2 diabetic men. Adiponectin also showed a significant positive association with HDL - C in controls [r - 0.948; p = 0.01] and cases with type 2 diabetes [r - 0.860; p = 0.01]. Conclusion:
Serum adiponectin level is markedly decreased in type 2 diabetic cases. Moreover, it is associated positively with HDL - C and negatively with HbA[1]c and TG levels. Hypoadiponectinaemia is associated with deranged glycaemic status and lipid profile in men having type 2 diabetes mellitus
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Biomedica
Year:
2013
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