Evaluation of therapeutic value of human chorionic gonadotrophin [HCG] in children with unilateral undescended testes [Cryptorchidism]

ABSTRACT

The present study was undertaken to determine the therapeutic effect of HCG [1500 U/M, IM, twice weekly 4 weeks] on 50 children with unilateral cryptorchidism, inguinal [n=36], high scrotal [n=6] and intraabdominal [n=8]. Testicular descent has been accomplished, completely in 5.6% and partially in 22.2%, of children with unilateral inguinal testis. Eighty three% of high scrotal testes descended to the bottom of scrotum after HCG therapy, whereas none of the intraabdominal testes did change their position after hormonal therapy. Significant enlargement of testicular and penile size was observed in all the study children after HCG treatment. This finding proved normal Lydig cell function and sensitive androgenic receptors in patients with unilateral crytorchidism