Antimicrobial activity of some antiprotozoal drugs

ABSTRACT

In this investigation antibacterial and antifungal activities of graded increased concentrations of some antiprotozoal drugs were studied. The minimal inhibitory concentrations [MIC] of these drugs against sensitive bacterial strains were determined. Diminazene aceturate in concentrations of 5, 1, 5, 50, 10 and 1 mg/ml inhibited growth of Staph. aureus, C. pyogens, Esch coli. S. typhi, Psaeruginosa and P. multocida respectively. It also ihibited growth of C. albicans. A. niger, A. flavus, A. fumigatus, A. gepsum and T. mentagrophytes in concentrations of 5, 1, 1, 5, 50 mg/ml. Its minimal inhibitory concentration against these organisms ranges from 0.146 to 0.669 mg/ml. Quinapyramine in concentrations of 10, 10, 20, 100 and 10 mg/ml inhibited growth of Staph. aureus C. pyogens Esch. coli, S. typhimurium and Ps. aerugienosa. This drug in concentrations of 100, 100, 10, 100, and 100 mg/ml inhibited growth of C. albicans, A. niger, A flavus, A. fumigatus and T. mentagrophytes. The minimal inhibitory concentrations of quinapyramine against the previously mentioned sensitive bacterial strains ranged from 0.345 to 1.025 mg/ml. Quinuronium sulphate inhibited growth of C. pyogens only and had no effect on the growth of other bacterial strains. The drug in concentration of 50 mg/ml had inhibitory effect against C. albicans, A. niger and A. fumigatus. Naganol and ivermectin had no effect on the studied bacteria and fungi. In vivo study showed that daily dressing of pyogenically infected wounds with 10 and 20% of diminazens aceturate and quinapyramine led to their complete healing within 6 and 8 days of infection corresponding to 5 days for terramycin treated wounds