Clinical significance of esophageal groove-vasopressin induced-closure: 1-A new concept in the treatment of non specific diarrhoea in adult buffaloes

ABSTRACT

The effect of lysine-vasopressin on oesophageal groove closure was studied in adult buffaloes. Sixteen animals were allocated to 4 groups. Each group was tested for the effect of the dose rate 0.01, 0.03, 0.2 or 0.5 I.U/Kg IBW respectively. Both efficiency and period of closure were determined by indirect methods. Efficient and prolonged closure was achieved by the dose 0.5 I.U/Kg, a reliable effect by 0.2 I.U/Kg, while 0.03 was the least effective. Furthermore, 23 adult buffaloes suffered from non specific diarrhoea, were treated symptomatically with ADD-charcoal mixture given as a drench once daily for 3 successive days. Eight animals received the mixture alone, 10 animals received the mixture after premedication with lysine-vasopressin at the dose rate of 0.2 I.U/Kg IBW. The other animals remained without treatment as control. Animals premedicated with lysine-vasopressin showed rapid and high recovery with clinical improvement in feacal character, bodily condition, P.C.V.% and total proteins. The other animals showed no perceivable improvement