Therapeutic effects of total alkaloids of fructus hordei germinatus in hyperprolactinemis rats

ABSTRACT

Fructus Hordei Germinatus is widely used in treating hyperprolactinemia as a kind of Chinese traditional herb in China. However, its active composition of curing hyperprolactinemia remains unclear. This study investigates the activity of total alkaloids of F. H. Germinatus [AFH] in hyperprolactinemia rats. High-dose, middle-dose and low-dose AFH were administered into the stomach of hyperprolactinemia rats for 30 days. It revealed that high-dose AFH had obvious curative effect in treating hyperprolactinemia. It could regulate serum E2, P, PRL, FSH, LH levels to normal, decrease the pituitary prolactin positive cell number, mRNA expression level and inhibit the hyperplasia of mammary gland in hyperprolactinemia model rats effectively. The F. H. Germinatus contained total alkaloids 42. 74 +/- 0. 08mg hordenine equivalent [HE]/g the sample using acid dye colorimetry method. F. H. Germinatus should be developed as an anti-hyperprolactinemia product deeply