relationship between clinicobiochemical markers and depression in women with polycystic ovary syndrome

ABSTRACT

Previous studies have demonstrated that clinical features of 16TPolycystic ovary syndrome16T [PCOS] are associated with a lower degree of health, self, and sex satisfaction. Our study aimed to investigate possible associations between depression and different clinicobiochemical markers of PCOS. In a cross-sectional analytic study, 120 PCOS women aged 18-45 yr, were enrolled. Beck Depression Inventory was used to assess depression. Also, all participants underwent biochemical studies. Individuals with 15 points and more in Beck test were referred to a psychiatrist to participate in a complementary interview for the diagnosis of depression based on Diagnostic and Statistical Manual of Mental Disorders IV [DSMIV-TR] criteria. Among the study participants, 82 women [68.3%] were non-depressed, and 38 patients [31.7%] had some degrees of depression. According to the psychiatric interview, 10 patients [8.3%] had major depression, 22 patients [18.3%] had minor depression and 6 patients [5%] had dysthymia. We failed to show any significant difference in body mass index, hirsutism, infertility, serum total testosterone, lipid profile, and the homeostasis model assessment of insulin resistance [HOMA-IR] between depressed and non-depressed subjects [p>0.05]. Using Spearman correlation, we did not find a positive correlation between BDI scores and clinicobiochemical markers for all PCOS subjects [-0.139 0.05]. In spite of high rate of depression in women with PCOS, there was no significant association between Clinicobiochemical Markers and depression