Pirfenidone treatment in idiopathic pulmonary fibrosis: a Saudi experience

ABSTRACT

Recent trials involving pirfenidone suggest a beneficial effect in the treatment of idiopathic pulmonary fibrosis [IPF]. To report on the efficacy and safety of pirfenidone in the treatment of patients with IPF, at a tertiary care hospital in Saudi Arabia. The study included 58 patients with IPF who were evaluated from March 2012 to March 2013. During the study period, 33 patients received pirfenidone, and the remaining patients [n = 25] served as a control group. Baseline clinical characteristics, physiological parameters and the results of a 36-Item Short Form Health Survey [SF-36] were compared between the groups. Furthermore, we compared changes in forced vital capacity [FVC], diffusion capacity of the lung for carbon monoxide [DLco], six-minute walk distance [6MWD] and SF-36 for both groups during follow-up. The last follow-up period ended in January 2014. There were no significant differences in baseline clinical characteristics between the groups. Furthermore, we found no differences in FVC, DLco and SF-36 during follow-up [median, 12 months]. However, patients receiving pirfenidone treatment were less likely to experience reductions in 6MWD compared with the control group [13% vs. 52%, respectively; P = 0.001]. Although adverse events were more frequently reported by the pirfenidone group compared with the control group [85 vs. 56%, respectively; P = 0.015], these patients did not require discontinuation of treatment. Pirfenidone treatment preserves functional capacity, as reflected by the 6MWD. Adverse events associated with pirfenidone treatment were generally well tolerated by the patients