Hyperinsulinemia and its association with polycystic ovarian syndrome

ABSTRACT

To determine the variable clinical presentation of Poly cystic ovarian Syndrome [PCOS] and its association with Hyperinsulinaemia in young adolescent girls. A descriptive study was conducted for one year from February 2009-2010 at Isra University Hospital Hyderabad [IUH]. 136 adolescent girls who came in OPD with suspected features of polycystic ovarian syndrome were recruited. Biochemical test, ultrasound of pelvis and test to determine hyperinsulinemia were done .woman having preexisting ovarian pathology were excluded. All results were analyzed on statistical software SPSS version 16. Frequencies and percentages were calculated. Result: Insulin resistance significantly increased [43.4%] in girls who have shown the features of PCOS. Weight gain observed in 69 [50.7% - Obese] and 40[29.4%- very obese] of girls respectively. Different types of menstrual irregularities such as oligomenorrhea 50[36.8%], secondary amenorrhea 28 [20.6%] primary amenorrhea 5 [3.7%] were observed. 53[39.0%] adolescent girls had normal cycle but evidence of PCO on ultrasound. Infertility was found in 32 [23.5%] of participant followed by hirsutism and acne in 59 [43.4%] 45 [33.1%] of woman respectively. There is significant association of PCOS with hyperinsulinemia. Hyperinsulinemia if persist can lead to metabolic syndrome with its serious sequelae .Steps should be taken for early recognition of PCOS in young woman