Flow-mediated vasodilatation; effect on cardiovascular function with and without fructose and sucralose in healthy, white European males

ABSTRACT

To assess whether flow-mediated dilatation [FMD] affected cardiovascular [CV] parameters after consuming fructose or sucralose. Data source Finometer. Design of study Randomized, cross-over, single-blind design. School of biomedical sciences, University of Nottingham, UK. July, 2009. Materials and Ten healthy, white European males were studied twice. A Finometer continuously recorded CV parameters. Following 30 min baseline, a BP cuff, around mid-point of right arm was inflated 50 mmHg above Systolic BP for 5 min. Upon deflation, FMD measurements were made. Volunteers then consumed 500 ml of fructose or sucralose containing drink. Forty min later, 2nd FMD was done. Pre-fructose FMD SBP increased in late-occlusion and post-occlusion period [POP]. HR and CO decreased and SV and TPR increased during POP [P < 0.01 and 0.001]. Post-fructose DBP rose [2 mmHg; P = 0.04] during occlusion; HR [P = 0.02] and CO [P < 0.05] increased whereas TPR decreased [0.023; P < 0.04] in recovery period. Pre-sucralose SBP, DBP and MAP increased in POP and thereafter. Decreased HR and CO and increased TPR and SV were noted [P < 0.01 and 0.001]. Post-sucralose SBP rose in POP and thereafter [5 mmHg; P < 0.01]; MAP [3 mmHg; P = 0.04] and SV [P = 0.05] increased in POP. Attenuated BP and TPR, after fructose, indicate fructose's possible vascular effects