Treatment updates regarding anaplastic oligodendroglioma and anaplastic oligoastrocytoma
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2014; 24 (12): 935-939
in English
| IMEMR
| ID: emr-154014
ABSTRACT
Anaplastic Oligodendroglioma / Anaplastic Oligoastrocytoma [AO/AOA] is a WHO Grade-III primary brain tumor. These tumors comprise about 5 - 10% of all gliomas, which make them the third most common primary brain tumors after glioblastoma multiforme and astrocytomas. For many years standard of treatment remained Maximum Safe Resection [MSR] followed by Radiotherapy [RT]. These tumors have also been known to be sensitive to alkylator-based chemotherapy particularly the subset having 1p/19q co-deletion signature. There is robust data showing that these tumors are responsive to chemotherapy in recurrent or progressive setting. Recently, up front chemotherapy has been added to standard post-surgery RT. It has been found that subset of AO/AOA having 1p/19q co-deletion responded very well to the addition of chemotherapy. This substantial benefit in terms of median Overall Survival [OS] and median Progression Free Survival [PFS] have intrigued the personalized treatment of AO/AOA on the basis of molecular signature markers
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Oligodendroglioma
/
Radiotherapy
/
Astrocytoma
/
Brain Neoplasms
/
Antineoplastic Agents
Limits:
Humans
Language:
English
Journal:
J. Coll. Physicians Surg. Pak.
Year:
2014
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