Buccoadhesive tablets for delivery of verapamil hci: design, in-vitro analysis and in-vivo evaluation

ABSTRACT

Buccoadhesive controlled release verapamil HCI tablets have been prepared using mucoadhesive polymers namely; sodium alginate [Na Alg], xanthan gum [XG] and gum tragacanth [GT] either alone or in combination in different ratios 28, 82, 46 and 64. The prepared tablets were evaluated for their weight variation, thickness, hardness, friability and dissolution, content uniformity, swelling index, in-vitro adhesion, in-vitro drug release and in-vivo hypertension study. Tablets containing XG showed the highest swelling index and bio adhesive force. The maximum cumulative% released [100%] was observed in F7, F10 and FJl due to high percent of Na alg. The kinetics studies show that the release follows zero order kinetics except Fl that it obeyes a diffusion model The buccoadhesive verapamil HCI tablet had suggested being promising for the transmucosal delivery of verapamil HCI and allowing a controlled drug delivery for 6 hrs