Role of fibulin-3 in the diagnosis of malignant mesothelioma
Egyptian Journal of Chest Diseases and Tuberculosis [The]. 2014; 63 (1): 99-105
in English
| IMEMR
| ID: emr-154299
ABSTRACT
Early detection of malignant pleural mesothelioma [MPM] is critical to survival, the use of pleural or blood fibuin-3 might allow this early detection. Studying the validity of measuring serum and pleural fibulin-3 in the diagnosis of MPM. Fibulin-3 levels were measured in serum and pleural fluid by enzyme-linked immunosorbant assay [ELISA] in 45 patients with exudative pleural effusion. Patients with non-conclusive cytology or microbiological examination had undergone medical thoracosope for histopathological examination. Twenty five was diagnosed as MPM, 11 cases as pleural metastasis of carcinoma [Mets] and nine cases with benign pleural effusions. Patients with MPM had significantly higher pleural effusion and serum fibulin-3 levels than those with metastatic effusion of carcinoma or benign pleural effusion [p-value < 0.001]. Using a cut-off point of pleural fluid fibulin-3 [150 ng/ml] with AUC of 0.878 [sensitivity 72.3%, specificity 80] and at a cut-off point of serum fibulin-3 [66.5 ng/ml], with AUC of 0.776 [sensitivity 88%, specificity 81.8%], discrimination between MPM and Mets occurred. Also, using a cut-off point of pleural fluid fibulin-3 [127.5 ng/ml] with AUC of 0.909 [sensitivity 88%, specificity 77.8%], and at a cut-off point of serum fibulin-3 [18 ng/ml], with AUC of 0.931 [sensitivity 100%, specificity 77.8%], discrimination between MPM and benign pleural effusion could occur. Fibulin-3 in the serum and pleural fluid is a good biomarker in the diagnosis of MPM and in differentiation between MPM from malignant pleural metastasis other than mesothelioma and also from benign pleural effusions
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Thoracoscopy
/
Enzyme-Linked Immunosorbent Assay
/
Biomarkers, Tumor
/
Tomography, X-Ray Computed
/
Extracellular Matrix Proteins
/
Hospitals, University
Type of study:
Screening study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Egypt. J. Chest Dis. Tuberc.
Year:
2014
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