Expressions and clinical significance of serum bone Gla-protein, bone alkaline phosphatase and C-terminal telopeptide of type I collagen in bone metabolism of patients with osteoporosis

ABSTRACT

This study aimed to evaluate the expressions and clinical significance of bone Gla-protein [BGP], bone alkaline phosphatase [B-ALP] and C-terminal telopeptide of type I collagen [CTX] in patients with osteoporosis [OP], and to provide evidence for developing individualized treatment plans. Seventy-two OP patients in our hospital were selected as an OP group, and another 72 healthy subjects were used as a control group. Their BGP, B-ALP and CTX levels as well as bone mineral density [BMD] values were measured. The correlations between BGP, B-ALP and CTX levels and BMD values were determined. The BGP level of the OP group [[5.61 +/- 5.52] ng/ml] was significantly higher than that of the control group [P<0.05], but the levels of B-ALP and CTX did not differ significantly [P>0.05]. The BMD values of femoral neck and Ward's triangle in the OP group were negatively correlated with the B-ALP levels [P<0.05]. For women OP patients, the BMD values of femoral neck and Ward's triangle were also negatively correlated with the B-ALP levels [P<0.05]. The BMD of femoral neck in the control group was negatively correlated with the CTX level [P<0.05]. Determining BGP, B-ALP and CTX levels can evaluate the bone metabolism degree, which provides evidence for clinical typing of OP and developing treatment strategies