Effects of curcumine on antioxidation in diabetic rats

ABSTRACT

To investigate the effects of curcumin on antioxidation and its mechanism in diabetic rat model. After streptozotocin [STZ] induced diabetic rat model, large, medium and small doses of curcumin group were partly given curcumin solution 200,100,50mg·kg-1, administered once a day, continuously 30 days. In 30th day, determine blood glucose [BG] value, after the last injection, determine the serum superoxide dismutase [SOD], malondialdehyde [MDA], glycosylated serum protein [GSP] and free fatty acid [FFA] levels. Compared with the model group rats, In the 10[th], 30[th] administrate, each dose of curcumin group rats' BG, MDA, GSP, FFA levels were significantly reduced, SOD levels was increased significantly. curcumin can significantly improve the antioxidant capacity of diabetic model, improve the metabolic disorder