effect of sodium hyaluronate treating knee osteoarthritis on synovial fluid interleukin -1beta and clinical treatment mechanism

ABSTRACT

In order to explore the influence of sodium hyaluronate on knee osteoarthritis [KOA] patients synovial fluid interleukin -1beta [IL-1beta] and analyze its clinical mechanism, this study analyzed 40 cases of KOA patients in our hospital's orthopaedic department, randomly divided them into two groups Sodium hyaluronate group [group A] and normal saline group [group B], each consists 20 patients. Besides, we selected another 20 patients as normal control group. Group A treated knee joint cavity by injecting sodium hyaluronate, and group B injected knee joint cavity in equal amount of normal saline, once a week for five weeks. Collect respectively knee joint synovial fluid in patients of group A and group B before treatment and after five weeks of treatment, detect the content of knee joint synovial fluid IL-1betain of all the three groups by using enzyme linked immunosorbent assay [ELISA]. We can conclude that [1] IL-1beta content of knee joint synovial fluid in KOA patients before treatment was significantly higher than healthy people; [2] IL-1beta content of group A knee joint synovial fluid after treatment was significantly reduced than before treatment, there was no significant difference for group B IL-1beta content before and after treatment; [3] there was no significant difference between group A knee joint synovial fluid IL-1beta content after treatment and healthy people. Thus it can be proved that content of IL-1beta in knee joint synovial fluid KOA patients is higher than healthy people; sodium hyaluronate can reduce the content of IL-1beta in synovial joints and can be effective in the treatment of knee osteoarthritis