Hepatoprotective effect of otostegia persica boiss. shoot extract on carbon tetrachloride-induced acute liver damage in rats
IJPR-Iranian Journal of Pharmaceutical Research. 2012; 11 (4): 1235-1241
in English
| IMEMR
| ID: emr-155478
ABSTRACT
In this study, the hepatoprotective effect of the methanol extract of aerial parts [shoot] from Otostegia persica Boiss [Golder] was investigated against the carbon tetrachloride [CCl[4]]-induced acute hepatotoxicity in male rats. Liver damage was induced through the oral administration of 50% CCl[4] in liquid paraffin [2.5 mL/Kg bw, per os] 60 min after the administration of the methanol extract of O. persica shoot [in 200, 300, 400 mg/Kg bw doses] and assessed using biochemical parameters [plasma and liver tissue malondialdehyde [MDA], transaminase enzyme levels in plasma [aspartate transaminase [AST], alanine aminotransferase [ALT]] and liver glutathione [GSH] levels]. Results show that the methanol extract of O. persica shoot is active at 300 mg/Kg [per os] and it possess remarkable antioxidant and hepatoprotective activities. Additionally, histopathological studies verified the effectiveness of this dose of extract in acute liver damage prevention
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rats
/
Carbon Tetrachloride
/
Plant Extracts
/
Rats, Wistar
/
Liver
Limits:
Animals
Language:
English
Journal:
Iran. J. Pharm. Res.
Year:
2012
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