[Comparing the analgesic effect pregabalin and gabapentin as premedication in laparoscopic procedures]

ABSTRACT

Laparoscopic surgery is associated with post operative pain . Optimal pain treatment with minimal side effects is essential for early recovery and mobility in patients undergoing laparoscopic surgery . We compared the analgesic effect Pregabalin and Gabapentin with different doses in these surgical procedures. In a randomized, double blind, ninety patients were allocated to either Group A Pregabalin 300mg, Group B Gabapentin 600mg and Group C Gabapentin 900mg. These were administered 1 h before operation .General anesthesia was performed . We collected data on pain intensity through Visual Analogue Scale [VAS] in recovery, 6, 24 h after operation. Consumption of supp Diclofenac was recorded. p<0.05 was considered statistically significant. Pregabalin 300 mg was significantly more effective in reducing post operative pain up to 24 hours following the surgery [p<0.001] . Furthermore, the amount of analgesic consumption was less in the Pregabalin group [p<0.001]. Consumption analgesic and VAS were more than the other groups in patient who receive Gabapentin 600 mg. Our finding showed that single dose of pregabalin 300mg oral is more effective than Gabapatin on the management of postoperative pain following abdominal laparoscopic surgery. And Pregabalin resulted in reduction in 24 h postoperative analgesic requirements. Gabapentin 900mg decrease VAS and consumption of analgesic significantly