[Effect of single dose premedication with pregabaline on pain after minor surgery]

ABSTRACT

Optimal postoperative pain management is necessary after minor general surgery. Although pregabalin had been showed efficacy against neuropathic pain, very limited evidence support its postoperative analgesic efficacy. The aim of this study was to evaluate the analgesic efficacy of premedication with single oral dose of pregabalin for minor general surgery. Sixty patients candidate for minor general surgery under general anesthesia were randomly allocated into the two groups; In intervention group Pregabalin 150mg, and in control group placebo was administered one hour before surgery. Anesthesia method was similar in both groups. If pain score [Visual Analogue Scale, VAS] was more than three, pethidine 25mg intravenous was administrated. VAS, opioid consumption, and side effects were recorded for 24 hours after surgery. Demographic data was not significantly different between two groups. VAS and opioid consumption during the 24 hours postoperative period in pregabalin group was significantly less than the placebo group without any more side effects [p<0.01]. Preoperative administration of single oral dose of pregabalin 150mg reduced post operative pain and opioid consumption for 24 hours following minor general surgery