Significant high lipid profile in pre-hypertensive subjects as compare to stage 1 and stage 2 of hypertensive subjects

ABSTRACT

To analyze the differences in lipid profile in various categories of hypertension in our local population. Cross Sectional Study. This study was conducted at Amin Hayat Memorial Trust for diabetes and Hypertension, Lahore and Punjab Institute of Cardiology [PIC], Lahore from Dec. 2005 to May 2007. A total of 510 subjects of either sex were screened during a cross-sectional study. Biochemical assessment includes the determination of TC [Total Cholesterol], LDL-C [Low Density Lipoprotein Cholesterol], HDL-C [High Density Lipoprotein Cholesterol], and TG [Triglycerides], which were measured by using commercially available kits using Hitachi 902 photometer. vLDL and LDL-C/HDL-C ratio was calculated by using formula. Abnormal lipid profile was observed in 59% of the study population. Around 75% of prehypertensive subjects had abnormal lipid profile as compare to stage 1 and stage 2 of hypenension. Beside prevalence significant high levels of TC, LDL-L, and LDL-C/HDL-C were also observed in prehypertensive group. Females had significantly high levels of TC, HDL-C and LDL-C/HDL-C compared to males. A high prevalence of dyslipidemia was observed in all stages of hypertension; however, prehypertensive group had significant high levels of lipid profile and smoking and family history also predispose to high blood pressure