liver in chronic renal failure: an ultrastructural study

ABSTRACT

The nature of the biochemical disturbances that cause the alteration in chronic renal failure with the consequent multi-system affection constitutes a major problem. The present study examined the hepatocytes in renal failure at the ultrastructural level. Liver samples were processed for electron microscopy and ultrathin sections were examined at a joel electron microscope. Several subcellular changes in the plasma membrane, mitochondria, rough endoplasmic reticulum and the nucleus were noticed. Such hepatocellular fine alteration might be responsible for certain laboratory and clinical features associated with the uremic syndrome