Triglyceride clearance in chronic renal failure

ABSTRACT

The clearance of exogenous triglycerides from the blood was studied after intravenous infection of intralipid in three groups of subjects. The first group included seven healthy controls, the second group comprised ten patients with chronic renal failure [CRF] on conservative medical treatment [CMR] and the third group consisted of six patients with end stage renal disease [ESRD] on maintenance hemodialysis [MH]. All controls and patients had normal fasting serum triglyceride level except one patient with CRF on CMR who had hypertriglyceridemia with an incidence of 6.3%. This was planned to eliminate the effect of hypertriglyceridemia perse on the fractional turnover rate of intralipid [K2]. The present study has shown that CRF patients with normal fasting serum triglyceride [TG] level and on CMR have impaired TG clearance that correlated negatively with their fasting serum TG levels, while those on MH have a normal TG clearance. results were discussed and compared with previous studies done on the same topic