Effect of methoxyverapamil, diltiazem, morphine and their combination on the formation of irreversibly sickled cells: an in vitro study
EMHJ-Eastern Mediterranean Health Journal. 1997; 3 (2): 301-309
in English
| IMEMR
| ID: emr-156469
ABSTRACT
The effect of methoxyverapamil and diltiazem [calcium antagonists] and morphine [calcium antagonist activity] on the formation of irreversibly sickled cells [ISCs] was investigated. Methoxyverapamil at therapeutic concentration and 10 times that level resulted in a 12% and 21% reduction in the formation of ISCs respectively, which was statistically significant. Diltiazem also produced a significant reduction in ISCs but morphine produced no significant reduction. Combination of these drugs produced a net effect similar to their individual effects. These drugs might be useful in decreasing the intensity of sickling crises and vaso-occlusive events. Thus in vivo trials in patients with sickle-cell disease are suggested
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Diltiazem
/
Gallopamil
/
Calcium
/
Anemia, Sickle Cell
/
Morphine
Limits:
Humans
Language:
English
Journal:
East Mediterr Health J.
Year:
1997
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