Cellular immune response in acute hepatitis B leading to chronic carrier state
EMHJ-Eastern Mediterranean Health Journal. 1997; 3 (2): 322-335
in English
| IMEMR
| ID: emr-156472
ABSTRACT
Immunological studies among jaundiced patients revealed significant changes in T-helper and T-suppressor cells among chronic HBV cases from the acute and control groups. The chronic cases revealed a highly significant decrease in interleukin-2R expression but their low interferon-gamma values were statistically nonsignificant from the control group. The acute cases recorded the highest interleukin-2R and interferon-gamma values. Lymphocyte blastogenesis assay in response to different mitogens and antigens produced two groups responders [acute cases] and nonresponders [chronic cases]. The responders revealed more intact specific and nonspecific cellular immune responses. Neither group differed with regard to their proliferative response to HBsAg, but vigorous response to HBcAg was a significant feature of the responders
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
T-Lymphocytes
/
Carrier State
/
Incidence
/
Risk Factors
/
Interferons
/
Interleukin-2
/
Immunity, Cellular
/
Liver Function Tests
Type of study:
Controlled clinical trial
/
Incidence study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
East Mediterr Health J.
Year:
1997
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