Defective monocyte phagocytic function as a possible genetic marker for heumatic susceptibility
EMHJ-Eastern Mediterranean Health Journal. 1998; 4 (1): 36-43
in English
| IMEMR
| ID: emr-156501
ABSTRACT
The activity of the monocyte phagocytic system in children with rheumatic heart disease [RHD], their parents, their normal siblings and in nonrheumatic families was investigated. Phagocytic activity of isolated monocytes was assessed using luminol-dependent chemiluminescence. The count per minute of emitted light was measured before and after stimulation with zymosan solution. The results indicate that one-third of the siblings of children with RHD were genetically free while two-thirds, as well as the parents, were heterozygous, and that children with RHD were homozygous for [a] mutant gene[s] responsible for the defective function of the monocyte phagocytic system. The findings are strongly suggestive of autosomal recessive inheritance
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Phagocytes
/
Rheumatic Fever
/
Monocytes
/
Genetic Markers
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
East Mediterr Health J.
Year:
1998
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