Pattern for alpha-thalassaemia in Yemeni sickle-cell-disease patients
EMHJ-Eastern Mediterranean Health Journal. 1999; 5 (6): 1159-1164
in English
| IMEMR
| ID: emr-156711
ABSTRACT
A group of Yemeni patients with sickle-cell disease [SCD] and normal Hb AA individuals living in Riyadh were studied to determine the incidence of the alpha-gene molecular defect. Blood samples were obtained from 26 SCD patients and 19 controls [the Hb AA group]. In the SCD patients the frequency of single alpha-gene deletion [-alpha/alpha alpha] was 0.346, compared to 0.263 in the Hb AA group. The frequency of two gene deletion [-alpha/-alpha] was 0.231 [0.0 for the Hb AA group]. In one Hb AA case, a triple alpha-gene arrangement [alpha alpha alpha/alpha alpha] was found [frequency 0.053]. The results suggest that alpha-thalassaemia occurs frequently in Yemeni SCD patients. Further studies to determine the overall frequency of alpha-thalassaemia in the Republic of Yemen would be of value for patient management
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Main subject:
Autoradiography
/
Case-Control Studies
/
Genetic Testing
/
Gene Deletion
/
Alpha-Thalassemia
/
Erythrocyte Count
/
Erythrocyte Indices
/
Gene Frequency
Limits:
Adolescent
/
Child
/
Humans
Language:
English
Journal:
East Mediterr Health J.
Year:
1999
Similar
MEDLINE
...
LILACS
LIS