Relation between hypercholesterolaemia and vascular endothelial microinflammation
EMHJ-Eastern Mediterranean Health Journal. 2007; 13 (3): 515-521
in English
| IMEMR
| ID: emr-157020
ABSTRACT
We investigated the correlation between hypercholesterolaemia and oxidative stress and P-selectin and interleukin-6 [IL-6] as markers for endothelial status. We studied 40 Egyptian adults with asymptomatic hypercholesterolaemia and 20 age- and sex-matched controls. Lipid peroxidation was significantly higher [P < 0.001] in the study group and positively correlated with cholesterol [P < 0.001] and low-density lipoprotein [LDL] [P < 0.002]. Glutathione peroxidase activity was also significantly higher [P < 0.001] with positive correlation with cholesterol [P < 0.001] and LDL [P < 0.001]. Markers for endothelial cell function were significantly higher in the study group [P < 0.001] with a positive correlation with cholesterol [P < 0.001] and LDL [P < 0.001]. Hypercholesterolaemia causes endothelial microinflammation, and P-selectin and IL-6 may also be risk factors for cardiovascular disease
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Vascular Diseases
/
Endothelium, Vascular
/
Cholesterol
/
Hypercholesterolemia
Limits:
Adult
/
Humans
Language:
English
Journal:
East Mediterr Health J.
Year:
2007
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