Serum levels of astroglial S100-beta and neuron-specific enolase in hepatic encephalopathy patients
EMHJ-Eastern Mediterranean Health Journal. 2007; 13 (5): 1114-1123
in English
| IMEMR
| ID: emr-157090
ABSTRACT
To find a reliable, noninvasive method for the diagnosis of cognitive impairment in patients with hepatic cirrhosis we measured serum levels of astroglial S100beta and neuron-specific enolase in cirrhotic patients with and without hepatic encephalopathy [HE]. S100beta levels showed a significant increase in groups with HE stage 1 and 2 compared to both control and cirrhosis patients. However serum neuron-specific enolase levels were not significantly different between the studied groups. S100beta levels had a specificity of 91.3% and sensitivity of 51.7% for detection of HE from cirrhosis. Serum S100beta may be a useful surrogate marker for the diagnosis of mild cognitive impairment in cirrhotic patients before they progress to more advanced stages of HE
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Phosphopyruvate Hydratase
/
Blood-Brain Barrier
/
S100 Proteins
/
Hepatic Encephalopathy
/
Sensitivity and Specificity
/
Ammonia
Limits:
Female
/
Humans
Language:
English
Journal:
East Mediterr Health J.
Year:
2007
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