Changes in adrenal steroidogenesis in spontaneous bacterial peritonitis and sterile ascites
EMHJ-Eastern Mediterranean Health Journal. 2008; 14 (6): 1301-1307
in English
| IMEMR
| ID: emr-157273
ABSTRACT
Adrenal androgens, particularly dehydroepiandrosterone [DHEA], may have important regulatory effects on the immune system in humans. This study measured the changes in adrenal steroidogenesis in 13 non-infected cirrhosis patients with sterile ascites and 13 patients with spontaneous bacterial peritonitis and the relation with circulating interleukin-6 [IL-6] levels. Comparisons were made with 10 healthy age-matched control subjects. The severity of bacterial peritonitis in liver cirrhosis was significantly associated with enhanced serum IL-6 and cortisol levels, and a decrease in serum DHEA sulfate in relation to serum IL-6 concentrations. Careful, long-term studies on DHEA administered to cirrhosis patients are needed to assess its safety in improving a number of pathological conditions that complicate liver cirrhosis
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Peritonitis
/
Ascites
/
Interleukin-6
/
Dehydroepiandrosterone
/
Adrenal Medulla
/
Androgens
/
Liver Cirrhosis
Limits:
Humans
Language:
English
Journal:
East Mediterr Health J.
Year:
2008
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