Study of aerobic granulocyte functional activity in the presence of a radiosensitizer [metronidazole]
EMHJ-Eastern Mediterranean Health Journal. 2009; 15 (1): 224-229
in English
| IMEMR
| ID: emr-157318
ABSTRACT
The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear [PMN] cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. At therapeutic doses of metronidazole [4.98-24.86 microg/mL] significant inhibition of the production of reactive oxygen species was noted in both methods. The inhibitory effect was in a dose-dependent pattern. The data suggest a scavenging mechanism of metronidazole on reactive oxygen species generated by PMN
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Main subject:
Radiation-Sensitizing Agents
/
Reactive Oxygen Species
/
Granulocytes
Language:
English
Journal:
East Mediterr Health J.
Year:
2009
Similar
MEDLINE
...
LILACS
LIS