T-cell cytokine production and endothelial dysfunction in type 2 diabetic patients with nephropathy
EMHJ-Eastern Mediterranean Health Journal. 2009; 15 (4): 807-816
in English
| IMEMR
| ID: emr-157383
ABSTRACT
This study assessed changes in serum levels of cytokines IFNgamma and IL-10 [biomarkers of inflammatory changes] and soluble biomarkers sICAM-1 and sE-selectin [biomarkers of endothelial dysfunction] in diabetic patients with and without nephropathy. IFNgamma and IL-10 were significantly elevated in patients with diabetic nephropathy [DN] and end-stage renal disease [ESRD] compared with controls and diabetic patients without DN. IFNgamma and IL-10 levels were significantly increased after haemodialysis. sICAM-1 and sE-selectin were significantly higher in diabetic, DN and ESRD groups compared with controls, and sICAM-1 but not sE-selectin was increased after haemodialysis
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
T-Lymphocytes
/
Renal Dialysis
/
Interferon-gamma
/
Interleukin-10
/
E-Selectin
/
Creatinine
/
Diabetes Mellitus, Type 2
/
Endothelium
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
East Mediterr Health J.
Year:
2009
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