Prevalence of factor V Leiden mutation in patients with thrombosis in Tunisia
EMHJ-Eastern Mediterranean Health Journal. 2009; 15 (6): 1483-1488
in English
| IMEMR
| ID: emr-157461
ABSTRACT
This study determined the prevalence of inherited factor V Leiden mutation in a group of 128 thrombosis patients [102 with venous thrombosis and 26 with arterial thrombosis] attending a hospital in Sousse, Tunisia, and a control group of 100 with no history of thrombosis. Using an allele-specific PCR amplification technique, factor V Leiden was found in significantly more patients [20.3%] than controls [6.0%]. The higher prevalence was significant in the subgroup of venous thrombosis patients but not in arterial thrombosis patients. The allele frequency was 3.5% in the normal Tunisian population. Screening Tunisian patients with venous thrombosis and their relatives for factor V Leiden may be justified
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Thrombosis
/
Polymerase Chain Reaction
/
Prevalence
/
Mutation
Type of study:
Prevalence study
Limits:
Humans
Language:
English
Journal:
East Mediterr Health J.
Year:
2009
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