Interleukin-17 gene expression and serum levels in acute rejected and non-rejected liver transplant patients
IJI-Iranian Journal of Immunology. 2014; 11 (1): 29-39
in English
| IMEMR
| ID: emr-157628
ABSTRACT
Interleukin-17 [IL-17], as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. However, there is not much information about the effects of IL-17 cytokine on acute liver rejection. To evaluate the role of IL-17 in post-liver transplant acute rejection. Ninety seven adult liver transplant patients who enrolled in this cross sectional study were divided into Non- Acute Rejected [Non-AR] and Acute Rejected [AR] patient groups. Three blood samples were collected from each patient in days 1, 4 and 7 post liver transplantation. The IL-17 mRNA levels were evaluated using an in-house real time PCR protocol. IL- 17 protein levels were also analyzed in Non-AR, AR and also control groups using ELISA method. The IL-17 mRNA expression level continuously increased in AR patients in all days of follow-up post liver transplantation. IL-17 expression was, however, down regulated after day 4 post-transplant follow-up in Non-AR patients. Both IL-17 mRNA expression and protein levels were also significantly increased in AR patients compared with Non-AR ones. Based on these findings, significant increase of IL-17 mRNA and protein levels in AR patients highlights the important role of IL-17 in acute liver rejection
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
RNA, Messenger
/
Enzyme-Linked Immunosorbent Assay
/
Gene Expression
/
Polymerase Chain Reaction
/
Liver Transplantation
/
Graft Rejection
/
Graft Survival
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Iran. J. Immunol.
Year:
2014
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