Tumour necrosis factor-alpha concentration in severely asthmatic children
EMHJ-Eastern Mediterranean Health Journal. 2000; 6 (2-3): 432-436
in English
| IMEMR
| ID: emr-157815
ABSTRACT
We assessed tumour necrosis factor-alpha [TNF-alpha] concentrations in 80 asthmatic children, 26 with severe asthma in early-phase reaction, 26 with severe asthma in late-phase reaction, 28 with severe asthma controlled in between attacks with oral prednisone and 20 matched control children. TNF-alpha was measured in patients' plasma and in a supernatant of lipopolysaccharide-stimulated [LPS] peripheral blood mononuclear [PBM] cells. TNF-alpha concentrations in plasma and the supernatant of LPS-stimulated cells were positively correlated and the concentration also correlated positively with the time lapse between the start of the asthma attack and the time of blood sampling. TNF-alpha concentration was significantly higher in the late-phase reaction group compared to the other groups, indicating a need to counteract its release and/or effects early in asthma patients
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Asthma
/
Child
/
Tumor Necrosis Factor-alpha
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
East Mediterr Health J.
Year:
2000
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