Effects of single-dose praziquantel on morbidity and mortality resulting from intestinal schistosomiasis
EMHJ-Eastern Mediterranean Health Journal. 2000; 6 (5-6): 926-931
in English
| IMEMR
| ID: emr-157868
ABSTRACT
The long-term effect of single-dose praziquantel on morbidity and mortality from Schistosoma mansoni was investigated in surveys in 1987 and 1994 in central Sudan. Prevalence of infection dropped from 53% to 34%, and intensity of infection [400 eggs/g of faeces] from 31% to 18%. There was a reduction in hepatomegaly and hepatosplenomegaly, although splenomegaly alone was unchanged. Prevalence of periportal fibrosis decreased from 14% to 10%. Endoscopic investigation of patients with fibrosis showed a reduction in oesophageal varices from 47% to 30%. Mortality due to bleeding varices was high [community-wide, up to 11/100 infected patients with bleeding]. Thus praziquantel mass treatment can be spaced to a much longer period, reducing the expense of treatment, delivery and distribution
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Main subject:
Praziquantel
/
Schistosomiasis mansoni
/
Esophageal and Gastric Varices
/
Prevalence
/
Liver Cirrhosis
Type of study:
Prevalence study
Limits:
Humans
Language:
English
Journal:
East Mediterr Health J.
Year:
2000
Similar
MEDLINE
...
LILACS
LIS