TNF-alpha and homocysteine levels in type 1 diabetes mellitus
EMHJ-Eastern Mediterranean Health Journal. 2001; 7 (4-5): 679-688
in English
| IMEMR
| ID: emr-157983
ABSTRACT
The role of homocysteine as an independent risk factor for vascular endothelial damage, and the possible link between homocysteine and tumour necrosis factor-alpha [TNF-alpha] as two synergistic risk factors for beta-cell apoptosis in type 1 diabetes mellitus was studied. Plasma homocysteine levels were significantly elevated in all diabetic patients compared with controls and diabetic patients with vascular complications showed higher elevations. Furthermore, homocysteine levels showed significant positive correlation with the degree of microalbuminuria. TNF-alpha levels were elevated in all diabetic patients compared with controls. These results may have therapeutic implications
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Main subject:
Glycated Hemoglobin
/
Cholesterol
/
Tumor Necrosis Factor-alpha
/
Apoptosis
/
Hyperhomocysteinemia
/
Diabetic Angiopathies
/
Diabetic Neuropathies
/
Albuminuria
/
Homocysteine
/
Cholesterol, LDL
Limits:
Adolescent
/
Female
/
Humans
/
Male
Language:
English
Journal:
East Mediterr Health J.
Year:
2001
Similar
MEDLINE
...
LILACS
LIS