New biochemical markers in chronic heart failure

E.M., El Bindary; A.Z., Darwish

E.M., El Bindary; A.Z., Darwish.

EMHJ-Eastern Mediterranean Health Journal. 2001; 7 (4-5): 697-706

in English | IMEMR | ID: emr-157985

ABSTRACT

ABSTRACT

We investigated the plasma levels of tumour necrosis factor-alpha [TNF-alpha], leptin and insulin, and their relation to body mass index [BMI] in 80 male patients who presented with chronic heart failure [mean age 47 +/- 4 years] at Tanta University Hospital. Plasma leptin, TNF-alpha and insulin were significantly increased and BMI significantly decreased in New York Heart Association classes III and IV patients. TNF-alpha, leptin and insulin were positively correlated, and TNF-alpha and BMI and leptin and BMI were negatively correlated in stages III and IV of heart failure. We conclude that cytokine neuroendocrine activation may form part of advanced stage heart failure. It may also be responsible for worsening cachexia, and can be used as a marker to determine disease severity

Subject(s)

Humans; Male; Middle Aged; Body Mass Index; Cachexia/diagnosis; Case-Control Studies; Chronic Disease; Heart Failure/blood; Hyperinsulinism/blood; Immunoenzyme Techniques; Insulin/blood; Leptin/blood; Neurosecretory Systems/physiopathology; Pulmonary Wedge Pressure; Radioimmunoassay

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Index: IMEMR (Eastern Mediterranean) Main subject: Cachexia / Radioimmunoassay / Body Mass Index / Case-Control Studies / Pulmonary Wedge Pressure / Chronic Disease / Immunoenzyme Techniques / Leptin / Heart Failure / Hyperinsulinism Limits: Humans / Male Language: English Journal: East Mediterr Health J. Year: 2001

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