Effect of interferon therapy on fatty acid saturation index in hepatitis C virus infection
EMHJ-Eastern Mediterranean Health Journal. 2001; 7 (4-5): 779-786
in English
| IMEMR
| ID: emr-157995
ABSTRACT
The ratio of stearic to oleic acids, i.e. the fatty acid saturation index, in red blood cell membranes was assayed in 60 patients with chronic hepatitis C virus infection before and after interferon-alpha therapy. Results were compared with 20 healthy controls. Hepatitis C virus titre was also assayed before and after interferon-alpha therapy. Within 2-5 months following interferon-alpha therapy, a significant inverse correlation was observed between saturation index and hepatitis C virus load. We conclude that hepatitis C virus infection enhances the degree of desaturation of 18-carbon fatty acids and that interferon-alpha is involved in their metabolism by increasing the degree of saturation and subsequent decrease in membrane fluidity
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Antiviral Agents
/
Stearic Acids
/
Stearoyl-CoA Desaturase
/
Severity of Illness Index
/
Oleic Acids
/
Biomarkers
/
Case-Control Studies
/
Chromatography
/
Viral Load
/
Hepatitis C, Chronic
Limits:
Humans
Language:
English
Journal:
East Mediterr Health J.
Year:
2001
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