Effect of dimethyl diphenyl bicarboxylate on normal and chemically-injured liver
EMHJ-Eastern Mediterranean Health Journal. 2002; 8 (1): 95-104
in English
| IMEMR
| ID: emr-158044
ABSTRACT
This study evaluates the effect of DDB on normal and chemically-injured liver. When given to normal rats DDB had no significant effect on liver enzymes, but in chemically-injured rats there was a significant decrease in the elevated levels of liver enzymes. DDB produced a significant increase in reduced glutathione, glutathione peroxidase and glutathione reductase, and a significant decrease in malondialdehyde and glucose-6-phosphate dehydrogenase in both normal and chemically-injured liver. The histopathology examinations showed a slight improvement with DDB administration. DDB has a beneficial effect on liver enzymes and possesses significant antioxidant properties in normal and chemically-injured liver, and may therefore be clinically useful in treating chronic viral hepatitis B in humans
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rats
/
Carbon Tetrachloride
/
Adjuvants, Immunologic
/
Cytochrome P-450 Enzyme System
/
Disease Models, Animal
/
Glutathione
/
Liver Diseases
/
Liver Function Tests
/
Malondialdehyde
/
Antioxidants
Limits:
Animals
Language:
English
Journal:
East Mediterr Health J.
Year:
2002
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