Effect of leptin on LH and FSH release in ovariectomized rats
EMHJ-Eastern Mediterranean Health Journal. 2002; 8 (1): 105-113
in English
| IMEMR
| ID: emr-158045
ABSTRACT
We compared the estradiol/progesterone-induced luteinizing hormone [LH] and follicle-stimulating hormone [FSH] release between normally fed and leptin-supplemented starved ovariectomized female rats and studied also the effect of hyper-leptinaemia on the steroid-induced hormonal release in normally fed ovariectomized rats. Three days' starvation completely abolished steroid-induced LH and FSH release. Significant recovery of the hormonal release was shown in the leptin-supplemented starved group. The magnitudes of LH and FSH release in the normally fed animals with a higher dose of leptin were statistically the same as those in the normally fed group without leptin. These observations indicate that physiological concentrations of circulating leptin exert a stimulatory effect on steroid-induced LH and FSH release
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rats
/
Neuropeptide Y
/
Luteinizing Hormone
/
Ovariectomy
/
Analysis of Variance
/
Disease Models, Animal
/
Follicle Stimulating Hormone
/
Hypothalamo-Hypophyseal System
Limits:
Animals
Language:
English
Journal:
East Mediterr Health J.
Year:
2002
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