Quinine for chloroquine-resistant falciparum malaria in pregnant Sudanese women in the first trimester
EMHJ-Eastern Mediterranean Health Journal. 2004; 10 (4-5): 560-565
in English
| IMEMR
| ID: emr-158321
ABSTRACT
A prospective clinical study in eastern Sudan described the efficacy and toxicity of quinine in early pregnancy in mothers with chloroquine-resistant falciparum malaria. Twenty-six pregnant Sudanese women in their first trimester [mean gestational age 8.5 weeks] were given quinine 10 mg/kg 3 times per day for 7 days and followed up every 2 weeks until delivery. One patient aborted [3.8%] and 2 patients [7.7%] experienced threatened abortion but delivered term babies. Recrudescence or re-infection was observed on day 21 in 1 patient. One baby died aged 6 months. There were no detectable congenital malformations, no auditory or visual defects or any other neurological deficits in the remaining infants at birth or 1 year later. Quinine may be safe in the first trimester of pregnancy
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Parasite Egg Count
/
Drug Resistance
/
Pregnancy Outcome
/
Chloroquine
/
Administration, Oral
/
Gestational Age
/
Endemic Diseases
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
East Mediterr Health J.
Year:
2004
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