Frequency of the CCR5-delta 32 chemokine receptor gene mutation in the Lebanese population
EMHJ-Eastern Mediterranean Health Journal. 2004; 10 (4-5): 671-675
in English
| IMEMR
| ID: emr-158336
ABSTRACT
A direct correlation between HIV infection and mutation in the chemokine receptor [CCR5] gene has been established. However, such correlation has never been investigated in Lebanon. We report the frequency of the CCR5-delta 32 mutation in a r and om sample of 209 healthy, HIV-1 seronegative Lebanese aged 19-68. Overall, 4.8% were heterozygous for the mutation. Homozygosity was absent from our sample. The frequency for the CCR5-delta 32 allele was 2.5%. Distribution of the mutation was unaffected by sex, age, religion or educational level. The frequency in the Lebanese population is consistent with that in the origin of the mutation in northern Europe. This could be attributed to a gene flow into the Middle East from northern Europe
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Main subject:
Blood Donors
/
Aged
/
Analysis of Variance
/
Frameshift Mutation
/
Gene Deletion
/
Gene Flow
/
Gene Frequency
/
Genetics, Population
Type of study:
Case report
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
East Mediterr Health J.
Year:
2004
Similar
MEDLINE
...
LILACS
LIS