Immunoinflammatory markers and disease activity in systemic lupus erythematosus: something old, something new
EMHJ-Eastern Mediterranean Health Journal. 2010; 16 (8): 893-900
in English
| IMEMR
| ID: emr-158500
ABSTRACT
This study assessed the utility of some novel inflammatory markers compared with traditional laboratory markers in patients with systemic lupus erythematosus [SLE]. In a cohort of 43 SLE patients [19 with inactive and 24 with active SLE] and 20 healthy controls, serial measures of soluble vascular cell adhesion molecule [sVCAM-1] were significantly associated with SLE disease activity, scored using the British Isles Lupus Assessment Group index. Inflammatory markers neopterin and soluble intercellular adhesion molecule [sICAM-1] appeared to be clinically useful for isolated assessments of disease activity. Both antibodies to double-stranded DNA [antidsDNA] and sVCAM-1 were relatively good markers of disease activity and could help to predict remission or monitor the therapeutic response in SLE
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Biomarkers
/
Intercellular Adhesion Molecule-1
/
Vascular Cell Adhesion Molecule-1
/
Lupus Erythematosus, Systemic
Limits:
Adult
/
Humans
Language:
English
Journal:
East Mediterr Health J.
Year:
2010
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