Interleukins 12 and 13 levels among beta-thalassaemia major patients
EMHJ-Eastern Mediterranean Health Journal. 2013; 19 (2): 181-185
in English
| IMEMR
| ID: emr-158911
ABSTRACT
The role of inflammatory cytokines in the pathophysiology of beta-thalassaemia is still unclear. In this study production levels of interleukins [IL]-12 and IL-13 were measured by commercial ELISA in cultureI supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. IL-12 levels were significantly lower among cases compared with controls [91.4 pg/mL versus 154.6 pg/mL] while IL-13 levels were significantly higher [42.5 pg/mLversus 5.7 pg/mL]. There was a significant negative correlation between IL-12 and IL-13 levels among beta-thalassaemia cases [r= -0.42]. Patients with beta-thalassaemia alone had higher IL-12 levels than beta-thalassaemia patients who were seropositive for chronic hepatitis B or C virus Infection [140 pg/mL versus 50 pg/mL]; IL-13 levels were slightly lower [65 pg/mL versus 67 pg/mL]. An imbalance In the IL-12/IL-13 axis may be relevant to the pathophysiology of beta-thalassaemia
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Enzyme-Linked Immunosorbent Assay
/
Case-Control Studies
/
Interleukin-13
/
Interleukin-12
/
Hepatitis B, Chronic
/
Hepatitis C, Chronic
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
East Mediterr Health J.
Year:
2013
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