Comparative proteomics study on meglumine antimoniate sensitive and resistant Leishmania tropica isolated from Iranian anthroponotic cutaneous leishmaniasis patients
EMHJ-Eastern Mediterranean Health Journal. 2012; 18 (2): 165-171
in English
| IMEMR
| ID: emr-158936
ABSTRACT
In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis [CL], we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. Cell proteins were analysed with 2-dimensional electrophoresis and differentially expressed proteins were identified by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed activated protein kinase c receptor [LACK], alpha tubulin [X2], prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. The study shows the usefulness of proteomics in identifying proteins that may express differences between sensitive and resistant L. tropica isolates
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Organometallic Compounds
/
Mass Spectrometry
/
Electrophoresis, Gel, Two-Dimensional
/
Leishmaniasis, Cutaneous
/
Proteomics
/
Meglumine
Limits:
Humans
Language:
English
Journal:
East Mediterr Health J.
Year:
2012
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