Relation between serum ferritin and liver and heart MRI T2* in beta thalassaemia major patients
EMHJ-Eastern Mediterranean Health Journal. 2013; 19 (8): 727-732
in English
| IMEMR
| ID: emr-159000
ABSTRACT
There is a need for higly accurate non-invasive methods for assessing organ iron content in thalassaemia patients. This study evaluated the relation between serum ferritin level, liver enzyme levels and hepatitis C antibody and liver and heart iron deposition assessed by MRI T2 Data were obtained from the medical records of 156 thalassemia major patients in Tehran. There was a moderate negative correlation between serum ferritin and liver MRI T2 relaxation time [r= -0.535] and a weak negative correlation between serum ferritin and heart MRI T2 relaxation time [r= -0.361]. Hepatitis C infection and liver enzyme levels did not confound or modify the relation between ferritin and liver or heart MRI T2. Liver and heart MRI T2* readings were poorly correlated [r= 0. 281]. Routine evaluation of liver and heart iron content using MRI T2 is suggested to better evaluate the haemosiderosis status in thalassemia patients
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Magnetic Resonance Imaging
/
Cross-Sectional Studies
/
Hepatitis C Antibodies
/
Ferritins
/
Heart
/
Iron
/
Liver
/
Liver Function Tests
Type of study:
Prevalence study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
East Mediterr Health J.
Year:
2013
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