Study of host immunity in patients with Helicobacter pylori-related idiopathic thrombocytopenia
EMHJ-Eastern Mediterranean Health Journal. 2013; 19 (7): 676-681
in English
| IMEMR
| ID: emr-159034
ABSTRACT
To test the role of T helper cell Th1 immunity we recruited 24 patients with idiopathic thrombocytopenia associated with H. pylori seropositivity. They were divided into 2 groups 12 with immune-mediated thrombocytopenia [Group 1] and 12 with non-immune mediated thrombocytopenia [Group 2]. We also recruited 10 individuals seronegative for H. pylori [Group 3] as controls. Initial platelet count was significantly lower in Group 1 than Group 2. H. pyloriwas eradicated in 10 of 12 patients in Group 1 and in all patients in Group 2. Transient improvement [< 3 months] in the platelet count occurred in only 2 patients in Group 1 while improvement for > 6 months was observed in all patients in Group 2. There was a statistically significant direct correlation between platelet count and levels of TNF- and IFN-gamma in both study groups, while a non-significant correlation was seen in Group 3. Thus, H. pyloriinfection should be considered in the differential diagnosis of all cases of thrombocytopenia, and should be eradicated in all H. pylori-positive patients with thrombocytopenia
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Platelet Count
/
Helicobacter pylori
/
Interferon-gamma
/
Tumor Necrosis Factor-alpha
/
T-Lymphocytes, Helper-Inducer
/
Immunity
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
East Mediterr Health J.
Year:
2013
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