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Detection and genotyping of human papillomavirus in breast cancer tissues from Iraqi patients
EMHJ-Eastern Mediterranean Health Journal. 2014; 20 (6): 372-377
in English | IMEMR | ID: emr-159232
ABSTRACT
Studies have suggested a possible link between breast cancer pathogenesis and human papillomavirus [HPV] infection. This study in Iraq used in situ hybridization to detect the frequency and genotyping of HPV in tissue specimens from 129 patients diagnosed with malignant breast cancer, 24 with benign breast tumours and 20 healthy controls. In the breast cancer group, cocktail HPV genotypes were detected in 60 [46.5%] archived tissue blocks. Of these, genotypes 16 [55.5%], 18 [58.4%], 31 [65.0%] and 33 [26.6%] were detected. Mixed HPV genotypes 16 + 18, 16 + 18 + 31, 16 + 18 + 33, 18 + 33, 16 + 31 and 18 + 31 were found in 5.0%, 25.0%, 8.3%, 7.7%, 10.0% and 13.3% of cancer cases respectively. Only 3 benign breast tumour tissues [12.5%] and none of the healthy breast tissue specimens were HPV-DNA-positive. The detection of high-oncogenic HPV genotypes in patients with breast cancer supports the hypothesis of an etiologic role for the virus in breast cancer development
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Index: IMEMR (Eastern Mediterranean) Main subject: Breast Neoplasms / Retrospective Studies / In Situ Hybridization / Human papillomavirus 16 / Human papillomavirus 18 / Human papillomavirus 31 / Genotyping Techniques / Genotype Limits: Female / Humans Language: English Journal: East Mediterr Health J. Year: 2014

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Index: IMEMR (Eastern Mediterranean) Main subject: Breast Neoplasms / Retrospective Studies / In Situ Hybridization / Human papillomavirus 16 / Human papillomavirus 18 / Human papillomavirus 31 / Genotyping Techniques / Genotype Limits: Female / Humans Language: English Journal: East Mediterr Health J. Year: 2014