Gestational diabetes mellitus and iron supplement; effects on pregnancy outcome

ABSTRACT

The possible effect of iron supplementation has been investigated in the normal population and patients with gestational diabetes mellitus [GDM]. In this study, we survey the risk factors of GDM in pregnant women in contrast with normoglycemic patients in a case control study in patients using iron supplement. This case control study conducted on 52 pregnant women with GDM [25 women with type Al and 27 women with Type A2 of GDM]. The control group randomly selected 50 normoglycemic women. Venous blood sampling was done between 24 and 28 weeks of pregnancy for measuring of ferritin, lipoproteins, uric acid and malondialdehyde serum levels. Under study variables including age, gestational age, weight and BMI were gathered. All the women were followed up until the time of delivery and pregnancy outcome were gathered. The serum ferritin levels in GDM group was 31.22+15.44, which is significantly higher than 24.76+8.94, in the control group with [P=0.012]. Plasma hemogulobin in the control group was 12.2+0.1 compared to 12.9+0.1 in GDM group which was significantly lower [P=0.005]. Triglycerides was significantly higher in GDM group in contrast with the control group, 275.08+143.17 and 192.30+92.13 [P=0.001], respectively. Finally, our findings indicate the concentration of serum ferritin levels was significantly higher in The GDM group